A review on computational approaches that support the researches on traditional Chinese medicines (TCM) against COVID-19COVID-19에 대한 전통적인 중국 의약품 (TCM)에 대한 연구를 지원하는 계산 접근법에 대한 검토Review Published on 2022-09-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 신약개발, 치료제, [키워드] antiviral agent Antiviral agents antiviral medication applied approach approaches article articles artificial intelligence AutoDock AutoDock vina category caused Chinese collected complex mechanism complex mechanisms Compound computational approach Computational approaches computational method contagious infection contagious infections COVID-19 database death Direct direct-acting Diseases disrupting Drug discovery effort eligible examined exclusion criteria Google Scholar Gromacs help highlight include Inclusion Knowledge-mining lead MD simulation Medicine molecular docking molecular mechanism Network-based approach other diseases Prevention and control Prophylactic provided required Research ResearchGate resource retrieved Science Science Direct Structure-based approach Support targets TCM TCMSP Traditional Traditional Chinese medicine Traditional Chinese Medicine (TCM). Vaccine Web of Science [DOI] 10.1016/j.phymed.2022.154324 PMC 바로가기 [Article Type] Review
COVID-19 management landscape: A need for an affordable platform to manufacture safe and efficacious biotherapeutics and prophylactics for the developing countriesCOVID-19 관리 환경: 개발도상국을 위한 안전하고 효과적인 바이오 치료제 및 예방제를 제조하기 위한 저렴한 플랫폼의 필요성Review Published on 2022-08-262022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 신약개발, 진단, [키워드] adopted adoption African antibody approach approach approaches Asian Biotherapeutics concern country COVID-19 COVID-19 pandemic dependency effective Factors globe help lead less logistics management monoclonal antibodies monoclonal antibody Monoclonal antibody cocktail Multiantigen vaccine National Pichia Pichia pastoris platform prophylactic strategy Prophylactics raw material recombinant vaccine Research Safe SARS-CoV-2 SARS-CoV-2 variants supply the SARS-CoV-2 therapeutic vaccination Vaccine variants variants of concern. yeast [DOI] 10.1016/j.vaccine.2022.05.065 PMC 바로가기 [Article Type] Review
Squalene in oil-based adjuvant improves the immunogenicity of SARS-CoV-2 RBD and confirms safety in animal models오일 기반 보조제의 스쿠알렌은 SARS-CoV-2 RBD의 면역원성을 개선하고 동물 모델에서 안전성을 확인합니다Article Published on 2022-08-232022-09-11 Journal: PLoS ONE [Category] SARS, 변종, 진단, 치료기술, [키워드] accelerated adjuvant Analysis animal model assays binding Cellular immune response Chromatography conditions COVID-19 demonstrated determine determined by elicited ELISA etiologic agent evaluated expressed flow cytometry Formulation hamsters histopathological humoral immune immunization immunogenicity IMPROVE insect cell insect cells kidney lead liver Lungs mice Neutralizing antibodies neutralizing antibody pandemic Protein purified RBD of SARS-CoV-2 RBD protein receptor Safe SARS-CoV-2 SARS-CoV-2 RBD sera shown squalene stimulate sub-unit vaccine the Spike Vaccine vaccine candidate variant virus water [DOI] 10.1371/journal.pone.0269823 PMC 바로가기 [Article Type] Article
Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T H 2-biased immunizationT H 2 편향 예방 접종 후 COVID-19 햄스터의 백신 관련 향상된 호흡기 병리학Article Published on 2022-08-162022-09-11 Journal: Cell Reports [Category] 유전자 메커니즘, 진단, [키워드] ADE alum animals antibody Antibody-dependent enhancement caused cellular coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccines CP: Immunology CP: Microbiology cytokine cytokine driver cytokine drivers Cytokines Dexamethasone dexamethasone treatment dysregulation eosinophil evaluate hamster host gene identify IL-13 IL-4 IL-5 immune immune responses immunization immunology Immunopathogenesis induce Infection interleukin lead lung lymphoid cell lymphoid cells Macrophage macrophages measles virus mechanism mechanism of immunopathogenesis Microbiology mRNA mRNAs pathology PROTECT Protein Protein vaccines respiratory Respiratory disease respiratory infections reveal RNA sequencing scRNA-seq Single-cell RNA sequencing Spike protein T helper TH2 immune responses transcriptomic analysis Treatment up-regulating vaccination Vaccine vaccine safety vaccine-associated enhanced respiratory disease. VAERD virus [DOI] 10.1016/j.celrep.2022.111214 PMC 바로가기 [Article Type] Article
Upregulation of PD-1 Expression and High sPD-L1 Levels Associated with COVID-19 SeverityCOVID-19 심각성과 관련된 PD-1 발현 및 높은 sPD-L1 수치의 상향 조절Article Published on 2022-08-012022-09-11 Journal: Journal of Immunology Research [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] (PD-1 addition association Biomarker CD14 CD14+ monocyte CD14+ monocytes CD19 CD19+ cellular COVID-19 COVID-19 patients death Depletion evaluated Exhaustion expression Frequency increase in Infection inhibiting inhibitor lead Level lymphocyte Lymphocytes mechanism monocyte Monocytes Patient PD-1 Protein SARS-COV-2 infection SARS-CoV-2-infected patients severity TCD4 TCD8 the disease therapeutic target These cells These data with COVID-19 [DOI] 10.1155/2022/9764002 PMC 바로가기 [Article Type] Article
Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5SARS-CoV-2 오미크론 하위 변이체 BA.2.12.1, BA.4 및 BA.5에 의한 항체 회피Article Published on 2022-08-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Analysis antibodies antibody antigenic bebtelovimab breakthrough infections Clinical use COVID-19 vaccine COVID-19 vaccines dominant Efficacy evade facilitate individual lead Lineage Mutation Neutralizing antibodies omicron raise receptor Receptor-binding domain Region residue SARS-CoV-2 sera South Africa Spike protein Spike proteins the receptor-binding domain the United State therapeutic therapeutic antibodies United States vaccine breakthrough infections Viral yielding [DOI] 10.1038/s41586-022-05053-w PMC 바로가기 [Article Type] Article
The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach새로운 SARS-CoV-2 변이체 Omicron(B.1.1.529)이 백신 효능에 미치는 영향, Delta 변이체와의 상관관계: 전산적 접근Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Analysis antibody approach AY.1 B.1.1.529 binding affinity caused computational analysis correlation COVID CR3022 Delta Delta variants docking docking analysis domain Effect Efficacy Host hosts human ACE2 receptor human monoclonal antibodies Human monoclonal antibody immune evasion in silico Approach In-silico analysis Interaction lead MD simulation Modification Mutation neutralizing antibody new SARS-CoV-2 omicron Omicron variant Omicron. pathogenicity promote Proteins RBD RBD variant Reinfection SARS-CoV-2 variant Spike proteins Strains Structure the binding affinity the WHO Vaccine variant [DOI] 10.1016/j.micpath.2022.105619 PMC 바로가기 [Article Type] Article
Increased plasma level of soluble P-selectin in non-hospitalized COVID-19 convalescent donors입원하지 않은 COVID-19 회복기 기증자에서 가용성 P-셀렉틴의 혈장 수준 증가Article Published on 2022-08-012022-09-11 Journal: Thrombosis research [Category] MERS, 바이오마커, 임상, [키워드] Activation acute disease baseline characteristics Biomarker Blood blood donor Blood donors blood sampling CD62P Characteristics Coagulation Coagulation system comparable Control controls convalescent coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors COVID-19 diagnosis COVID-19 symptom COVID-19 symptoms decrease demonstrated disease disease severity Donor donors ELISA endothelial evaluated Factor flow cytometry hospitalized COVID-19 patient hospitalized COVID-19 patients implication in vitro Increased lead longitudinal study marker Moderate COVID-19 MOST non-infected P-selectin Participation phenotype plasma plasma concentration Plasma marker plasma samples Platelet platelet activation Platelet function procoagulant questionnaire recruited reported Research SARS-CoV-2 SARS-COV-2 infection significantly higher Soluble P-selectin. study groups suffered systemic disease Transmission Trial Vascular was determined was measured was obtained was performed were recorded [DOI] 10.1016/j.thromres.2022.06.014 PMC 바로가기 [Article Type] Article
Induced humoral immunity of different types of vaccines against most common variants of SARS-CoV-2 in Egypt prior to Omicron outbreak오미크론 발병 이전 이집트에서 가장 흔한 SARS-CoV-2 변종에 대한 다양한 유형의 백신에 대한 체액성 면역 유도Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S AstraZeneca B.1 BBIBP-CorV BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 collected COVID-19 COVID-19 pandemic Delta Diversity effective Effectiveness elicited Humoral immunity induced janssen lead microneutralization Microneutralization assay Neutralizing activity Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses new SARS-CoV-2 omicron outbreak participant Pfizer-BioNTech SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccine SARS-CoV-2 variants Sinopharm the SARS-CoV-2 Vaccine vaccine effectiveness. vaccine-induced antibodies vaccine-induced antibody variant variants variants of SARS-CoV-2 was determined while [DOI] 10.1016/j.vaccine.2022.05.086 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTDRBD 및 NTD를 표적으로 하는 한 쌍의 중화 항체에 대한 SARS-CoV-2 탈출 돌연변이의 특성화Article Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] active immunization Affect antibodies antibody binding Cell culture characterization Clinical use Cluster Combination Efficacy escape escape mutant escape mutants escape mutation gene segments Genetic human immunoglobulin identify immunization immunization strategies Immunoglobulin indicate lead mice monoclonal monoclonal antibodies monoclonal antibody more difficult Mutation mutations neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody nine not affected NTD pair passage pseudotype RBD RBD mutations reduced SARS-CoV-2 SARS-CoV-2 escape mutations SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein targeting the RBD the spike protein variable region variant variants variants of concern variants of concern. VoC [DOI] 10.3390/ijms23158177 PMC 바로가기 [Article Type] Article